A Potential Clinical Use for Methylphenidate with Tricyclic Antidepressants
Seven patients with recurrent refractory psychotic depressive illness were treated with tricyclic antidepressants plus methylphenidate (Ritalin). The effect of methylphenidate appears to involve an increase in the blood levels of antidepressants through enzymatic inhibition of the metabolism of imip...
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| Veröffentlicht in: | The American journal of psychiatry 1971-06, Vol.127 (12), p.1619-1625 |
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| container_end_page | 1625 |
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| container_issue | 12 |
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| container_title | The American journal of psychiatry |
| container_volume | 127 |
| creator | WHARTON, RALPH N PEREL, JAMES M DAYTON, PETER G MALITZ, SIDNEY |
| description | Seven patients with recurrent refractory psychotic depressive illness were treated with tricyclic antidepressants plus methylphenidate (Ritalin). The effect of methylphenidate appears to involve an increase in the blood levels of antidepressants through enzymatic inhibition of the metabolism of imipramine and desmethylimipramine that is concomitant with clinical improvement. The potentiation by methylphenidate may have important implications for the treatment of depression. |
| doi_str_mv | 10.1176/ajp.127.12.1619 |
| format | Article |
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The effect of methylphenidate appears to involve an increase in the blood levels of antidepressants through enzymatic inhibition of the metabolism of imipramine and desmethylimipramine that is concomitant with clinical improvement. 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| ispartof | The American journal of psychiatry, 1971-06, Vol.127 (12), p.1619-1625 |
| issn | 0002-953X 1535-7228 |
| language | eng |
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| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Adult Aged Animals Chloral Hydrate - therapeutic use Chromatography, Thin Layer Depression - drug therapy Depression - enzymology Desipramine - antagonists & inhibitors Desipramine - blood Desipramine - therapeutic use Dextroamphetamine - metabolism Drug Synergism Electroconvulsive Therapy Female Haplorhini Humans Imipramine - antagonists & inhibitors Imipramine - blood Imipramine - therapeutic use Liver - metabolism Male Methylphenidate - metabolism Methylphenidate - pharmacology Methylphenidate - therapeutic use Mice Middle Aged Psychotherapy Rats |
| title | A Potential Clinical Use for Methylphenidate with Tricyclic Antidepressants |
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