A Potential Clinical Use for Methylphenidate with Tricyclic Antidepressants

Seven patients with recurrent refractory psychotic depressive illness were treated with tricyclic antidepressants plus methylphenidate (Ritalin). The effect of methylphenidate appears to involve an increase in the blood levels of antidepressants through enzymatic inhibition of the metabolism of imip...

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Veröffentlicht in:	The American journal of psychiatry 1971-06, Vol.127 (12), p.1619-1625
Hauptverfasser:	WHARTON, RALPH N, PEREL, JAMES M, DAYTON, PETER G, MALITZ, SIDNEY
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Chloral Hydrate - therapeutic use Chromatography, Thin Layer Depression - drug therapy Depression - enzymology Desipramine - antagonists & inhibitors Desipramine - blood Desipramine - therapeutic use Dextroamphetamine - metabolism Drug Synergism Electroconvulsive Therapy Female Haplorhini Humans Imipramine - antagonists & inhibitors Imipramine - blood Imipramine - therapeutic use Liver - metabolism Male Methylphenidate - metabolism Methylphenidate - pharmacology Methylphenidate - therapeutic use Mice Middle Aged Psychotherapy Rats
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Zusammenfassung:	Seven patients with recurrent refractory psychotic depressive illness were treated with tricyclic antidepressants plus methylphenidate (Ritalin). The effect of methylphenidate appears to involve an increase in the blood levels of antidepressants through enzymatic inhibition of the metabolism of imipramine and desmethylimipramine that is concomitant with clinical improvement. The potentiation by methylphenidate may have important implications for the treatment of depression.
ISSN:	0002-953X 1535-7228
DOI:	10.1176/ajp.127.12.1619