Effects of Methylphenidate on Avoidance Learning in the Aged Rat

Twenty Sprague Dawley rats, aged 22 to 26 months were given subcutaneous injections of 4.5 mg/kg methylphenidate or distilled water. Twelve minutes after the single injection was given, rats began 90 trials of avoidance conditioning. Drug animals made significantly more correct responses than did th...

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Veröffentlicht in:	The Journal of general psychology 1977-04, Vol.96 (2), p.263-266
Hauptverfasser:	Glock, Dana, Gauron, Eugene F., Rowley, Vinton N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Avoidance Learning - drug effects Conditioning, Operant - drug effects Female Male Methylphenidate - pharmacology Motor Activity - drug effects Rats Sex Factors
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Beschreibung
Zusammenfassung:	Twenty Sprague Dawley rats, aged 22 to 26 months were given subcutaneous injections of 4.5 mg/kg methylphenidate or distilled water. Twelve minutes after the single injection was given, rats began 90 trials of avoidance conditioning. Drug animals made significantly more correct responses than did the control animals. Results indicate that use of methylphenidate in aged rats improved avoidance learning.
ISSN:	0022-1309 1940-0888
DOI:	10.1080/00221309.1977.9920823