The “graft versus leukemia” effect under conditions of mixed chimeric hemopoiesis
The "graft versus leukemia" effect can be induced in (C57B1/6×DBA) F^sub 1^ mice by two transplantations of cell suspensions containing bone marrow cells and splenocytes of (CBA×C57B1/6) F^sub 1^ mice and an injection of cyclophosphamide. The recipients of cell allotransplants were charact...
Gespeichert in:
Veröffentlicht in: | Bulletin of experimental biology and medicine 1997-05, Vol.123 (5), p.490-492 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | The "graft versus leukemia" effect can be induced in (C57B1/6×DBA) F^sub 1^ mice by two transplantations of cell suspensions containing bone marrow cells and splenocytes of (CBA×C57B1/6) F^sub 1^ mice and an injection of cyclophosphamide. The recipients of cell allotransplants were characterized by mixed chimeric hemopoiesis. These data outline a new approach to induction of the graft versus leukemia effect, requiring no complete elimination of the recipient's hemopoiesis and characterized by a low probability of lethal graft-versus-host reaction.[PUBLICATION ABSTRACT] |
---|---|
ISSN: | 0007-4888 1573-8221 |
DOI: | 10.1007/BF02445328 |