The “graft versus leukemia” effect under conditions of mixed chimeric hemopoiesis

The "graft versus leukemia" effect can be induced in (C57B1/6×DBA) F^sub 1^ mice by two transplantations of cell suspensions containing bone marrow cells and splenocytes of (CBA×C57B1/6) F^sub 1^ mice and an injection of cyclophosphamide. The recipients of cell allotransplants were charact...

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Veröffentlicht in:Bulletin of experimental biology and medicine 1997-05, Vol.123 (5), p.490-492
Hauptverfasser: Seledtsova, G. V., Seledtsov, V. I., Avdeev, I. V., Samarin, D. M., Kozlov, V. A.
Format: Artikel
Sprache:eng
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Zusammenfassung:The "graft versus leukemia" effect can be induced in (C57B1/6×DBA) F^sub 1^ mice by two transplantations of cell suspensions containing bone marrow cells and splenocytes of (CBA×C57B1/6) F^sub 1^ mice and an injection of cyclophosphamide. The recipients of cell allotransplants were characterized by mixed chimeric hemopoiesis. These data outline a new approach to induction of the graft versus leukemia effect, requiring no complete elimination of the recipient's hemopoiesis and characterized by a low probability of lethal graft-versus-host reaction.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02445328