The direction of vasomotor effects of thrombin is regulated by vascular tone

The direction of vasomotor effects of thrombin is regulated by vascular tone

Experiments on circular preparations of rat aortic arch show that after an increase in vascular tone thrombin-induced vasoconstriction is replaced by vasodilation. This effect is observed when vascular tone is modified with norepinephrine or prostaglandinF2α. Mechanical de-endothelialization abolish...

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Veröffentlicht in:Bulletin of experimental biology and medicine 1997-04, Vol.123 (4), p.316-318
Hauptverfasser: Sergeev, I. Yu, Bashkov, G. V.
Format: Artikel
Sprache:eng
Schlagworte:
Aorta
Aortic arch
Fainting
Norepinephrine
Thrombin
Vasoconstriction
Vasodilation
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Zusammenfassung:Experiments on circular preparations of rat aortic arch show that after an increase in vascular tone thrombin-induced vasoconstriction is replaced by vasodilation. This effect is observed when vascular tone is modified with norepinephrine or prostaglandinF2α. Mechanical de-endothelialization abolishes dilation and has no effect on constriction. Dilation is blocked by incubation with nitroarginine.
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02766174