Does trimetazidine act as antioxidant?

Does trimetazidine act as antioxidant?

Trimetazidine is 2-fold inferior to probucol in antioxidant activity measured using the model of copper-induced free radical oxidation of human plasma lipoproteins. EPR-spectroscopy shows that trimetazidine forms no free-radical intermediates in the presence of generated lipid alkoxyl or hydroxyl ra...

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Veröffentlicht in:Bulletin of experimental biology and medicine 1998-11, Vol.126 (5), p.1132-1134
Hauptverfasser: Tikhaze, A. K., Lankin, V. Z., Kolycheva, S. V., Konovalova, G. G., Shumaev, K. B., Kozachenko, A. I., Gurevich, S. M., Zharova, E. A., Smirnov, L. D.
Format: Artikel
Sprache:eng
Schlagworte:
Free radicals
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Zusammenfassung:Trimetazidine is 2-fold inferior to probucol in antioxidant activity measured using the model of copper-induced free radical oxidation of human plasma lipoproteins. EPR-spectroscopy shows that trimetazidine forms no free-radical intermediates in the presence of generated lipid alkoxyl or hydroxyl radicals, while probucol under these conditions forms phenoxyl radicals. Trimetazidine does not interact with superoxide radicals generated in the xanthinexanthine oxidase system, since it does not inhibit reduction of tetrazolium nitroblue. However, indirect effect of trimetazidine on free radical oxidation cannot be excludedin vivo.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02447254