Effect of buspiron on formation of acquired helplessness

By decreasing anxiety and emotional stress, buspiron in doses of 1 and 5 mg/kg decelerates the formation of instrumental defense reflex and increases the incidence of acquired helplessness in rats trained under conditions of highly indefinite environment. Buspiron in a dose of 0.5 mg/kg apparently d...

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Veröffentlicht in:Bulletin of experimental biology and medicine 1998-09, Vol.126 (3), p.896-898
Hauptverfasser: Toloknov, A. V., Averkina, N. A., Khitrov, N. K., Fisenko, V. P.
Format: Artikel
Sprache:eng
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Zusammenfassung:By decreasing anxiety and emotional stress, buspiron in doses of 1 and 5 mg/kg decelerates the formation of instrumental defense reflex and increases the incidence of acquired helplessness in rats trained under conditions of highly indefinite environment. Buspiron in a dose of 0.5 mg/kg apparently does not affect the optimal emotional background, thus promoting attaining the goal of conditioned reflex activity and not leading to an increase in the incidence of acquired helplessness.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02447368