Role of transforming growth factor-[beta] in erythroid cell-mediated suppression of B-cell blastogenesis

Role of transforming growth factor-[beta] in erythroid cell-mediated suppression of B-cell blastogenesis

Soluble products spontaneously secreted by murine nuclear erythroid cells directly suppress the proliferation of activated B-lymphocytes induced by bacterial lipopolysaccharides. Blocking of the transforming growth factor-β synthesis in nuclear erythroid cells by antisense oligonucleotides binding m...

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Veröffentlicht in:Bulletin of experimental biology and medicine 1997-11, Vol.124 (5), p.1107
Hauptverfasser: Seledtsova, G V, Seledtsov, V I, Samarin, D M, Taraban, V Ya, Sennikov, S V, Kashchenko, E A, Kozlov, V A
Format: Artikel
Sprache:eng
Schlagworte:
Cells
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Zusammenfassung:Soluble products spontaneously secreted by murine nuclear erythroid cells directly suppress the proliferation of activated B-lymphocytes induced by bacterial lipopolysaccharides. Blocking of the transforming growth factor-β synthesis in nuclear erythroid cells by antisense oligonucleotides binding mRNA and blocking of this factor's functional activity by neutralizing antibodies were associated with a marked decrease in suppressor activity of the medium conditioned by nuclear erythroid cells.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02445675