The role of intracellular Ca2+ pool in sodium nitroprusside-induced relaxation of rat aorta smooth muscle cells

The role of intracellular Ca2+ pool in sodium nitroprusside-induced relaxation of rat aorta smooth muscle cells

A relaxation effect of sodium nitroprusside on smooth muscle cells of rat aorta due to intracellular Ca^sup 2+^-store refilling is demonstrated using the double sucrose gap technique. It is suggested that sodium nitroprusside-induced repolarization of the smooth muscle cell membrane is associated wi...

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Veröffentlicht in:Bulletin of experimental biology and medicine 1999-02, Vol.127 (2), p.160-162
Hauptverfasser: Kovalev, I. V., Baskakov, M. B., Kapilevich, L. V., Medvedev, M. A., Panov, A. A., Popov, A. G.
Format: Artikel
Sprache:eng
Schlagworte:
Cells
Coronary vessels
Muscular system
Permeability
Smooth muscle
Sodium
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Zusammenfassung:A relaxation effect of sodium nitroprusside on smooth muscle cells of rat aorta due to intracellular Ca^sup 2+^-store refilling is demonstrated using the double sucrose gap technique. It is suggested that sodium nitroprusside-induced repolarization of the smooth muscle cell membrane is associated with inhibition of Ca permeability and/or Ca-dependent K^sup +^ permeability of the plasma membrane.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433102