Effects of polyphenol compounds fromAlchemilla vulgaris on morphofunctional state of thyroid gland in rats exposed to low temperature

In control rats and animals receiving polyphenol compounds extracted fromAlchemilla vulgaris, intense cooling stimulated synthesis of thyroid hormones and promoted their peripheral deiodination. In control rats, the period of recovery after cooling (readaptation period) was characterized by a compensatory reduction in thyroid function. In rats receiving test preparation, this period was characterized by significant activation of thyroid hormone synthesis and by further growth of reserve follicles that appeared during the cooling.[PUBLICATION ABSTRACT]