Cyclic Fever in Hodgkin's Disease (Pel–Ebstein Fever)

Figure 1. A 50-year-old man had fever, night sweats, and nonproductive cough for 10 weeks. He took antipyretic medications during the febrile periods. His wife recorded his temperatures, shown above, on 56 of the 71 days. Biopsy of a rapidly enlarging cervical lymph node revealed nodular sclerosing Hodgkin's lymphoma. The patient's fevers and other symptoms promptly disappeared after the first cycle of doxorubicin, bleomycin, vinblastine, and dacarbazine.