MRI Visualization of Melanoma Cells by Targeting Overexpressed Sialic Acid with a GdIII-dota-en-pba Imaging Reporter

MRI Visualization of Melanoma Cells by Targeting Overexpressed Sialic Acid with a GdIII-dota-en-pba Imaging Reporter

By design: The novel MRI reporter GdIII‐dota‐en‐pba (see picture) selectively binds to sialic acid residues, which are overexpressed on tumors. This imaging reporter accumulates in a murine melanoma B16‐F10 mice xenograft and from the MRI signal intensity it is possible to quantify the sialic acid c...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-01, Vol.52 (4), p.1161-1164
Hauptverfasser: Geninatti Crich, Simonetta, Alberti, Diego, Szabo, Ibolya, Aime, Silvio, Djanashvili, Kristina
Format: Artikel
Sprache:eng
Schlagworte:
imaging agents
molecular recognition
phenylboronates
sialic acids
tumor targeting
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Zusammenfassung:By design: The novel MRI reporter GdIII‐dota‐en‐pba (see picture) selectively binds to sialic acid residues, which are overexpressed on tumors. This imaging reporter accumulates in a murine melanoma B16‐F10 mice xenograft and from the MRI signal intensity it is possible to quantify the sialic acid concentration that is directly associated with tumor malignancy.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201207131