Biomimetic Three-Component Assembly of the Central Core of Halichonadins K and L

The one‐step cascade assembly of the central core of halichonadins K and L, two dimeric sesquiterpenoids of marine origin, is described for a model system providing suitable conditions towards the total synthesis of the two molecules. A biomimetic multicomponent reaction involving a glycine, a C5 unit presumably derived from lysine, and an isocyanide mimic of the terpene decalins is studied. A one‐pot multicomponent reaction involving the reaction of an isocyanide with an in situ generated dihydropyridinium salt permits a straightforward access to a biomimetic model of the recently isolated halichonadins K and L.