Efficient Manganese/Copper Bimetallic Catalyst for N-Arylation of Amides and Sulfonamides Under Mild Conditions in Water

An efficient and mild method using a bimetallic MnF2/CuI catalyst at 60 °C in water was developed for the N‐arylation of amides and sulfonamides with aryl halides. A variety of functionalized amides and sulfonamides were coupled with different substituted aryl halides to afford the corresponding N‐arylated products in good to excellent yields (up to 97 %). An efficient method using a bimetallic MnF2/CuI catalyst in combination with trans‐1,2‐diaminocyclohexane as the ligand has been developed for the cross‐coupling of benzamides and sulfonamides with differently substituted aryl iodides in water. The corresponding N‐arylated products were obtained in good to excellent yields (up to 97 %) under the catalytic conditions.