ChemInform Abstract: Synthesis of New Fluorine-Containing Pyrazolo[3,4-b]pyridinones as Promising Drug Precursors

The approaches to the synthesis of earlier unknown title compounds containing the 4‐ArSCF2 and 4‐ArSCHF groups involve i) direct annulation of substituted aminopyrazoles (I) with halogenated acetoacetates like (II), (V), and (X), and ii) replacement of the Br atom of the 4‐CF2Br group, or the Cl ato...

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Veröffentlicht in:	ChemInform 2012-04, Vol.43 (17), p.no-no
Hauptverfasser:	Golubev, A. S., Starostin, G. S., Chunikhin, K. S., Peregudov, A. S., Rodygin, K. C., Rubtsova, S. A., Slepukhin, P. A., Kuchin, A. V., Chkanikov, N. D.
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Sprache:	eng
Schlagworte:	Atoms & subatomic particles fused pyridine derivatives ring closure reactions
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creator	Golubev, A. S. Starostin, G. S. Chunikhin, K. S. Peregudov, A. S. Rodygin, K. C. Rubtsova, S. A. Slepukhin, P. A. Kuchin, A. V. Chkanikov, N. D.
description	The approaches to the synthesis of earlier unknown title compounds containing the 4‐ArSCF2 and 4‐ArSCHF groups involve i) direct annulation of substituted aminopyrazoles (I) with halogenated acetoacetates like (II), (V), and (X), and ii) replacement of the Br atom of the 4‐CF2Br group, or the Cl atom of the 4‐CHFCl group by sodium arenethiolates (VII) and (XII).
doi_str_mv	10.1002/chin.201217166
format	Article
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title	ChemInform Abstract: Synthesis of New Fluorine-Containing Pyrazolo[3,4-b]pyridinones as Promising Drug Precursors
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