ChemInform Abstract: Synthesis of New Fluorine-Containing Pyrazolo[3,4-b]pyridinones as Promising Drug Precursors

ChemInform Abstract: Synthesis of New Fluorine-Containing Pyrazolo[3,4-b]pyridinones as Promising Drug Precursors

The approaches to the synthesis of earlier unknown title compounds containing the 4‐ArSCF2 and 4‐ArSCHF groups involve i) direct annulation of substituted aminopyrazoles (I) with halogenated acetoacetates like (II), (V), and (X), and ii) replacement of the Br atom of the 4‐CF2Br group, or the Cl ato...

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Veröffentlicht in:ChemInform 2012-04, Vol.43 (17), p.no-no
Hauptverfasser: Golubev, A. S., Starostin, G. S., Chunikhin, K. S., Peregudov, A. S., Rodygin, K. C., Rubtsova, S. A., Slepukhin, P. A., Kuchin, A. V., Chkanikov, N. D.
Format: Artikel
Sprache:eng
Schlagworte:
Atoms & subatomic particles
fused pyridine derivatives
ring closure reactions
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Zusammenfassung:The approaches to the synthesis of earlier unknown title compounds containing the 4‐ArSCF2 and 4‐ArSCHF groups involve i) direct annulation of substituted aminopyrazoles (I) with halogenated acetoacetates like (II), (V), and (X), and ii) replacement of the Br atom of the 4‐CF2Br group, or the Cl atom of the 4‐CHFCl group by sodium arenethiolates (VII) and (XII).
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201217166