ChemInform Abstract: Use of Alkyl 2,4,6-Triisopropylbenzoates in the Asymmetric Homologation of Challenging Boronic Esters

ChemInform Abstract: Use of Alkyl 2,4,6-Triisopropylbenzoates in the Asymmetric Homologation of Challenging Boronic Esters

Addition of α‐lithiated alkyl 2,4,6‐triisopropylbenzoates (I) to boronic esters (II) leads to boron‐ate complexes which rapidly undergo 1,2‐metallate rearrangement to give homologated products (III).

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Veröffentlicht in:ChemInform 2012-04, Vol.43 (15), p.no-no
Hauptverfasser: Larouche-Gauthier, Robin, Fletcher, Catherine J., Couto, Irantzu, Aggarwal, Varinder K.
Format: Artikel
Sprache:eng
Schlagworte:
alcohols (benzene compounds)
diastereoselective syntheses
diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism)
enantioselective syntheses (incl. cis/trans-isomerism)
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Zusammenfassung:Addition of α‐lithiated alkyl 2,4,6‐triisopropylbenzoates (I) to boronic esters (II) leads to boron‐ate complexes which rapidly undergo 1,2‐metallate rearrangement to give homologated products (III).
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201215058