Synthesis and Antimicrobial Evaluation of New Monocyclic [beta]-Lactams

Synthesis and Antimicrobial Evaluation of New Monocyclic [beta]-Lactams

A simple, practical, and efficient approach to synthesize new series of 2-(3-(2,4-dichlorophenoxy)-2-(4-(dimethylamino)phenyl)-4-oxoazetidin-1-ylamino)-N-arylacetamide by Staudinger [2 + 2] cycloaddition reaction. The titled compounds were evaluated for their antibacterial and antifungal activity ag...

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Veröffentlicht in:Journal of heterocyclic chemistry 2012-09, Vol.49 (5), p.1151
Hauptverfasser: Pagadala, Ramakanth, Meshram, Jyotsna S, Chopde, Himani N, Jetti, Venkateshwarlu, Chidurala, Praveen, Kusampally, Uppalaiah
Format: Artikel
Sprache:eng
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Zusammenfassung:A simple, practical, and efficient approach to synthesize new series of 2-(3-(2,4-dichlorophenoxy)-2-(4-(dimethylamino)phenyl)-4-oxoazetidin-1-ylamino)-N-arylacetamide by Staudinger [2 + 2] cycloaddition reaction. The titled compounds were evaluated for their antibacterial and antifungal activity against eight microorganisms. All the newly synthesized compounds are characterized by IR, 1H-NMR, and mass spectroscopic data. [PUBLICATION ABSTRACT]
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.973