Solvent-Free Synthesis of 2-(Phenylamino)-4-(trifluoromethyl)-1,6-dihydropyrimidine Derivatives Catalyzed by Sulfamic Acid

Solvent-Free Synthesis of 2-(Phenylamino)-4-(trifluoromethyl)-1,6-dihydropyrimidine Derivatives Catalyzed by Sulfamic Acid

A series of 2‐(phenylamino)‐4‐(trifluoromethyl)‐1,6‐dihydropyrimidine derivatives were synthesized efficienly via the reaction of aryl aldehyde, ethyl 4,4,4‐trifluoro‐3‐oxobutanoate and 1‐phenylguanidine carbonate catalyzed by sulfamic acid under solvent‐free conditions. This protocol has the advant...

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Veröffentlicht in:Journal of heterocyclic chemistry 2012-09, Vol.49 (5), p.1033-1037
Hauptverfasser: Shen, Shide, Yang, Weihua, Yu, Chenxia, Li, Tuanjie, Yao, Changsheng
Format: Artikel
Sprache:eng
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Zusammenfassung:A series of 2‐(phenylamino)‐4‐(trifluoromethyl)‐1,6‐dihydropyrimidine derivatives were synthesized efficienly via the reaction of aryl aldehyde, ethyl 4,4,4‐trifluoro‐3‐oxobutanoate and 1‐phenylguanidine carbonate catalyzed by sulfamic acid under solvent‐free conditions. This protocol has the advantages of mild condition, high yields and environmentally benign procedure.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.912