Plasmonic Nanostructures for SERRS Multiplexed Identification of Tumor-Associated Antigens

Plasmonic Nanostructures for SERRS Multiplexed Identification of Tumor-Associated Antigens

Gold nanostructures obtained by laser ablation in solution are functionalized with antibodies for two tumor‐associated antigens (PSMA and PSCA) overexpressed by prostate cancer cells and are incubated with cancer cells expressing one of the antigens, both or none. SERRS multiplexing measurements all...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2012-12, Vol.8 (24), p.3733-3738
Hauptverfasser: Meneghetti, Moreno, Scarsi, Alessia, Litti, Lucio, Marcolongo, Gabriele, Amendola, Vincenzo, Gobbo, Marina, Di Chio, Marzia, Boscaini, Anita, Fracasso, Giulio, Colombatti, Marco
Format: Artikel
Sprache:eng
Schlagworte:
antibodies
Antigens, Neoplasm - analysis
Cell Line, Tumor
Gold
GPI-Linked Proteins - analysis
Humans
Kallikreins - analysis
Male
Metal Nanoparticles - ultrastructure
nanostructures
Nanotechnology
Neoplasm Proteins - analysis
plasmons
prostate cancers
Prostate-Specific Antigen - analysis
Prostatic Neoplasms - chemistry
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - immunology
SERRS
Spectrum Analysis, Raman - methods
Surface Plasmon Resonance - methods
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Beschreibung
Zusammenfassung:Gold nanostructures obtained by laser ablation in solution are functionalized with antibodies for two tumor‐associated antigens (PSMA and PSCA) overexpressed by prostate cancer cells and are incubated with cancer cells expressing one of the antigens, both or none. SERRS multiplexing measurements allow their identification and show a great targeting specificity.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201201196