Combined network and mathematical modeling suggests novel inflammation positive feedback circuit and role for IL-1 [alpha] in experimental trauma/hemorrhage and hepatocyte hypoxia

Assigning biologically plausible functions to directed edges of the network resulted in a so-called incoherent type I feed forward loop that predicted pulsatile, "gatekeeperâ[euro] behavior for the cytokine IL-1α--a behavior that was indeed observed in preliminary studies in mice subjected to T/HS.