ChemInform Abstract: Cysteine as a Sustainable Sulfur Reagent for the Protecting-Group-Free Synthesis of Sulfur-Containing Amino Acids: Biomimetic Synthesis of L-Ergothioneine in Water

ChemInform Abstract: Cysteine as a Sustainable Sulfur Reagent for the Protecting-Group-Free Synthesis of Sulfur-Containing Amino Acids: Biomimetic Synthesis of L-Ergothioneine in Water

The preparation of L‐ergothioneine (IV) and 2‐thiohistidine compounds in a one‐pot, two‐step procedure in water involves the regioselective, bromine‐induced introduction of cysteine followed by thermal cleavage in the presence of a thiol.

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Veröffentlicht in:ChemInform 2012-12, Vol.43 (51), p.no-no
Hauptverfasser: Erdelmeier, Irene, Daunay, Sylvain, Lebel, Remi, Farescour, Laurence, Yadan, Jean-Claude
Format: Artikel
Sprache:eng
Schlagworte:
amino acids
amino acids, peptides
biomimetic syntheses
peptides
S-alkylation
sulfonation
sulfuration
sulfuration, sulfonation, S‐alkylation
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Beschreibung
Zusammenfassung:The preparation of L‐ergothioneine (IV) and 2‐thiohistidine compounds in a one‐pot, two‐step procedure in water involves the regioselective, bromine‐induced introduction of cysteine followed by thermal cleavage in the presence of a thiol.
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201251154