Tracking the Bioreduction of Disulfide-Containing Cationic Dendrimers

Tracking the Bioreduction of Disulfide-Containing Cationic Dendrimers

Disulfides enhance the transfection efficacy and reduce the toxicity of cationic gene delivery polymers. A quantitative analysis is provided of the bioreduction of a dynamic bioreducible dendritic polycationic probe in four cell lines. Such knowledge is indispensible for understanding and optimizing...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2012-12, Vol.51 (50), p.12454-12458
Hauptverfasser: Brülisauer, Lorine, Kathriner, Nadia, Prenrecaj, Mark, Gauthier, Marc A., Leroux, Jean-Christophe
Format: Artikel
Sprache:eng
Schlagworte:
bioreducibility
Boron Compounds - chemistry
Caco-2 Cells
Cations - chemistry
Cell Line, Tumor
dendrimers
Dendrimers - chemistry
disulfide
Disulfides - chemistry
Drug Carriers - chemistry
drug delivery
HeLa Cells
Humans
Microscopy, Confocal
Oxidation-Reduction
Plasmids - genetics
Plasmids - metabolism
poly(amidoamine)
Polyamines - chemistry
Polymers - chemistry
Transfection
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Disulfides enhance the transfection efficacy and reduce the toxicity of cationic gene delivery polymers. A quantitative analysis is provided of the bioreduction of a dynamic bioreducible dendritic polycationic probe in four cell lines. Such knowledge is indispensible for understanding and optimizing bioreducible drug and gene delivery systems.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201207070