Investigating the Binding Mode of an Inhibitor of the MBNL1RNA Complex in Myotonic Dystrophy Type 1 (DM1) Leads to the Unexpected Discovery of a DNA-Selective Binder

Investigating the Binding Mode of an Inhibitor of the MBNL1RNA Complex in Myotonic Dystrophy Type 1 (DM1) Leads to the Unexpected Discovery of a DNA-Selective Binder

Recognition made easy: The selectivity of a small-molecule inhibitor that binds CTG and CUG sites with similar affinity can be shifted toward exclusive CTG recognition by a single N-methylation. Biophysical studies and MD simulations provide insights into the DNA and RNA recognition.

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Veröffentlicht in:Chembiochem : a European journal of chemical biology 2012-11, Vol.13 (17), p.2505
Hauptverfasser: Wong, Chun-Ho, Richardson, Stacie L, Ho, Yen-Jun, Lucas, Alex M. H, Tuccinardi, Tiziano, Baranger, Anne M, Zimmerman, Steven C
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Sprache:eng
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Zusammenfassung:Recognition made easy: The selectivity of a small-molecule inhibitor that binds CTG and CUG sites with similar affinity can be shifted toward exclusive CTG recognition by a single N-methylation. Biophysical studies and MD simulations provide insights into the DNA and RNA recognition.
ISSN:1439-4227
1439-7633