The First Catalytic Asymmetric Morita-Baylis-Hillman Reaction of Acrolein with Aromatic Aldehydes

We report the first example of catalytic asymmetric Morita-Baylis-Hillman reaction of acrolein with aromatic aldehydes. The use of 10 mol% of Hatakeyama＇s catalyst β-isocupreidine C4, in combination with 20 mol% of 2,6-dimethoxybenzoic acid, could catalyze the reaction to give the desired products i...

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Veröffentlicht in:	Chinese journal of chemistry 2012-11, Vol.30 (11), p.2631-2635
1. Verfasser:	曾兴平刘运林计从斌周剑
Format:	Artikel
Sprache:	eng
Schlagworte:	2,6‐dimethoxybenzoic acid 6-dimethoxybenzoic acid acrolein Aldehydes Baylis-Hillman反应 Morita-Baylis-Hillman reaction organocatalysis β-isocupreidine 不对称催化丙烯醛二甲氧基苯甲酸催化剂摩尔芳香醛
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Zusammenfassung:	We report the first example of catalytic asymmetric Morita-Baylis-Hillman reaction of acrolein with aromatic aldehydes. The use of 10 mol% of Hatakeyama＇s catalyst β-isocupreidine C4, in combination with 20 mol% of 2,6-dimethoxybenzoic acid, could catalyze the reaction to give the desired products in up to 81% ee.
ISSN:	1001-604X 1614-7065
DOI:	10.1002/cjoc.201200937