Organocatalytic Asymmetric Branching Sequence of MBH Carbonates: Access to Chiral Benzofuran-2(3H)-one Derivatives with Three Stereocenters

Organocatalytic Asymmetric Branching Sequence of MBH Carbonates: Access to Chiral Benzofuran-2(3H)-one Derivatives with Three Stereocenters

An organocatalytic asymmetric branching sequence was realized in the presence of 10 mol% of (DHQD)2AQN, affording the sequential products with three stereocentres, including two quaternary carbon centres, in 47%–79% yields with 85%–99% ee. An organocatalytic asymmetric branching sequence was realize...

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Veröffentlicht in:Chinese journal of chemistry 2012-11, Vol.30 (11), p.2693-2702
Hauptverfasser: Zhu, Chuanle, Yang, Lijun, Nie, Jing, Zheng, Yan, Ma, Junan
Format: Artikel
Sprache:eng
Schlagworte:
branching sequences
chloroaldoximes
enantioselectivity
Morita-Baylis-Hillman (MBH) carbonates
organocatalysis
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Zusammenfassung:An organocatalytic asymmetric branching sequence was realized in the presence of 10 mol% of (DHQD)2AQN, affording the sequential products with three stereocentres, including two quaternary carbon centres, in 47%–79% yields with 85%–99% ee. An organocatalytic asymmetric branching sequence was realized in the presence of 10 mol% of (DHQD)2AQN, affording the sequential products with three stereocentres, including two quaternary carbon centres, in 47%–79% yields with 85%–99% ee.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201200809