Enantioselective Morita-Baylis-Hillman Reaction Organocatalyzed by Glucose-based Phosphinothiourea

A class of bifunctional phosphinothioureas derived from saccharide was developed as new organocatalysts for the enantioselective Morita-Baylis-Hillman reaction between acrylates and aldehydes. With 10 mol% of glucose- based phosphinothiourea ld, the allylic alcohols were obtained in up to 96% yield...

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Veröffentlicht in:	Chinese journal of chemistry 2012-11, Vol.30 (11), p.2652-2656
1. Verfasser:	杨位红沙风张鑫袁奎伍新燕
Format:	Artikel
Sprache:	eng
Schlagworte:	acrylate asymmetric organocatalysis Baylis-Hillman反应 bifunctional phosphine chiral phosphinothiourea Morita-Baylis-Hillman reaction 丙烯酸酯反应条件基础对映体选择性有机催化剂烯丙基醇葡萄糖
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Beschreibung
Zusammenfassung:	A class of bifunctional phosphinothioureas derived from saccharide was developed as new organocatalysts for the enantioselective Morita-Baylis-Hillman reaction between acrylates and aldehydes. With 10 mol% of glucose- based phosphinothiourea ld, the allylic alcohols were obtained in up to 96% yield and 83% ee under mild reaction conditions.
ISSN:	1001-604X 1614-7065
DOI:	10.1002/cjoc.201200740