Acyclic Cucurbit[n]uril-Type Molecular Containers Bind Neuromuscular Blocking Agents InVitro and Reverse Neuromuscular Block InVivo

Acyclic Cucurbit[n]uril-Type Molecular Containers Bind Neuromuscular Blocking Agents InVitro and Reverse Neuromuscular Block InVivo

Be my guest: two acyclic cucurbit[n]uril-type receptors that carry SO(3) (-) -groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent...

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Veröffentlicht in:Angewandte Chemie International Edition 2012-11, Vol.51 (45), p.11358
Hauptverfasser: Ma, Da, Zhang, Ben, Hoffmann, Ulrike, Sundrup, Martina Grosse, Eikermann, Matthias, Isaacs, Lyle
Format: Artikel
Sprache:eng
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Zusammenfassung:Be my guest: two acyclic cucurbit[n]uril-type receptors that carry SO(3) (-) -groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block in rats.
ISSN:1433-7851
1521-3773