ChemInform Abstract: Organocatalyzed Michael-Henry Reactions: Enantioselective Synthesis of Cyclopentanecarbaldehydes via the Dienamine Organocatalysis of a Succinaldehyde Surrogate

Formal [3 + 2]cycloaddition of 4‐hydroxybut‐2‐enal, a succinaldehyde surrogate, with nitroalkenes in the presence of Jorgensen—Hayashi catalyst provides cyclopentanecarbaldehydes containing 4 consecutive stereogenic centers with excellent enantioselectivities.

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Bibliographische Detailangaben
Veröffentlicht in:	ChemInform 2012-11, Vol.43 (47), p.no-no
Hauptverfasser:	Hong, Bor-Cherng, Chen, Po-Yuan, Kotame, Prakash, Lu, Pei-Ying, Lee, Gene-Hsiang, Liao, Ju-Hsiou
Format:	Artikel
Sprache:	eng
Schlagworte:	cycloaddition reactions cyclopentane derivatives diastereoselective syntheses diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism) enantioselective syntheses (incl. cis/trans-isomerism)
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Beschreibung
Zusammenfassung:	Formal [3 + 2]cycloaddition of 4‐hydroxybut‐2‐enal, a succinaldehyde surrogate, with nitroalkenes in the presence of Jorgensen—Hayashi catalyst provides cyclopentanecarbaldehydes containing 4 consecutive stereogenic centers with excellent enantioselectivities.
ISSN:	0931-7597 1522-2667
DOI:	10.1002/chin.201247026