Potentiation of Hemostimulating Effects of Erythropoietin with Pegylated Hyaluronate-Endo-[beta]-N-Acetylhexosaminidase

Potentiation of Hemostimulating Effects of Erythropoietin with Pegylated Hyaluronate-Endo-[beta]-N-Acetylhexosaminidase

Pegylated hyaluronate-endo-β-N-acetylhexosaminidase considerably potentiates the hemostimulating effects of erythropoietin due to intensifi cation of proliferation and differentiation of erythroid precursors against the background of enhanced secretion of hemopoietins by nonadherent hemopoiesis-indu...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2012-09, Vol.153 (5), p.684
Hauptverfasser: Dygai, A M, Zyuz'kov, G N, Zhdanov, V V, Udut, E V, Gurto, R V, Miroshnichenko, L A, Simanina, E V, Khrichkova, T Iu, Stavrova, L A, Chaikovsky, A V, Artamonov, A V, Bekarev, A A, Madonov, P G, Minakova, M Iu, Markova, T S
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Sprache:eng
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Zusammenfassung:Pegylated hyaluronate-endo-β-N-acetylhexosaminidase considerably potentiates the hemostimulating effects of erythropoietin due to intensifi cation of proliferation and differentiation of erythroid precursors against the background of enhanced secretion of hemopoietins by nonadherent hemopoiesis-inducing environment cells and elevation of serum erythropoietin concentration. The use of the enzyme allows 10-fold reduction of the maximum effective erythropoietin dose.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1799-0