Synthesis of potentially bioactive PABA-related N-(aminoalkyl)lactamic amino acids and esters via selective S^sub N^Ar reactions

Synthesis of potentially bioactive PABA-related N-(aminoalkyl)lactamic amino acids and esters via selective S^sub N^Ar reactions

Issue Title: Peptides as Toxins/Defensins Potentially bioactive N-(aminoalkyl)lactamic amino acids and esters were synthesized in satisfactory to good yields by S^sub N^Ar reactions of aromatic acids with N-(3-aminopropyl)lactams followed by esterification with tertiary amino alcohols. The addition-...

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Veröffentlicht in:Amino acids 2011-01, Vol.40 (1), p.197
Hauptverfasser: Gonçalves, Renato S, Abdelnur, Patrícia V, Santos, Vanessa G, Simas, Rosineide C, Eberlin, Marcos N, Magalhães, Alviclér, Pérez González, Eduardo R
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Sprache:eng
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Zusammenfassung:Issue Title: Peptides as Toxins/Defensins Potentially bioactive N-(aminoalkyl)lactamic amino acids and esters were synthesized in satisfactory to good yields by S^sub N^Ar reactions of aromatic acids with N-(3-aminopropyl)lactams followed by esterification with tertiary amino alcohols. The addition-elimination S^sub N^Ar mechanism was confirmed by NMR and MS measurements.[PUBLICATION ABSTRACT]
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-010-0634-z