Synthesis of a new family of 2-ethylidene-[gamma]-unsaturated [delta]-amino esters via microwave activated Stille coupling

Synthesis of a new family of 2-ethylidene-[gamma]-unsaturated [delta]-amino esters via microwave activated Stille coupling

A simple approach to a new family of enantiomerically enriched polyunsaturated t-Boc-protected-δ-amino esters is described, via microwave promoted Stille coupling of (Z)-methyl-2-bromobutenoate with stannylated allylamines. The reaction conditions are mild and selective and disclose a simple way to...

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Veröffentlicht in:Amino acids 2010-06, Vol.39 (1), p.175
Hauptverfasser: Barozzino Consiglio, Gabriella, Gaggini, Francesca, Mordini, Alessandro, Reginato, Gianna
Format: Artikel
Sprache:eng
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Zusammenfassung:A simple approach to a new family of enantiomerically enriched polyunsaturated t-Boc-protected-δ-amino esters is described, via microwave promoted Stille coupling of (Z)-methyl-2-bromobutenoate with stannylated allylamines. The reaction conditions are mild and selective and disclose a simple way to 1-substituted butenoates of defined geometry.[PUBLICATION ABSTRACT]
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-009-0392-y