Protective effect of Panax ginseng against serum biochemical changes and apoptosis in kidney of rats treated with gentamicin sulphate
The protective effects of Panax ginseng (PG) on gentamicin sulphate (GS) induced acute nephrotoxicity were investigated in rats. A total of 32 adult Sprague–Dawley rats were randomly divided into 4 equal groups and treated by intraperitoneous route for 10 days with: 0.5 mL of isotonic saline (group...
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| Veröffentlicht in: | Journal of molecular histology 2012-10, Vol.43 (5), p.603-613 |
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| creator | Kalkan, Yildiray Kapakin, Kubra Asena Terim Kara, Adem Atabay, Tennur Karadeniz, Ali Simsek, Nejdet Karakus, Emre Can, Ismail Yildirim, Serap Ozkanlar, Seckin Sengul, Emin |
| description | The protective effects of
Panax ginseng
(PG) on gentamicin sulphate (GS) induced acute nephrotoxicity were investigated in rats. A total of 32 adult Sprague–Dawley rats were randomly divided into 4 equal groups and treated by intraperitoneous route for 10 days with: 0.5 mL of isotonic saline (group C), GS 100 mg/kg/day (group GS), co treatment PG (100 and 200 mg/kg/day) plus GS (100 mg/kg/day). After the last injection, kidney markers (urea, creatinine and blood urea nitrogen-BUN) and hepatic markers (aspartate aminotransferase-AST, alanine aminotransferase-ALT, gama glutamil transferase-GGT), and biochemical parameters were analyzed using diagnostic kits. Also, kidney changes were evaluated by immunohistochemical and stereological methods. GS treatment induced significant elevation (
P
|
| doi_str_mv | 10.1007/s10735-012-9412-4 |
| format | Article |
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Panax ginseng
(PG) on gentamicin sulphate (GS) induced acute nephrotoxicity were investigated in rats. A total of 32 adult Sprague–Dawley rats were randomly divided into 4 equal groups and treated by intraperitoneous route for 10 days with: 0.5 mL of isotonic saline (group C), GS 100 mg/kg/day (group GS), co treatment PG (100 and 200 mg/kg/day) plus GS (100 mg/kg/day). After the last injection, kidney markers (urea, creatinine and blood urea nitrogen-BUN) and hepatic markers (aspartate aminotransferase-AST, alanine aminotransferase-ALT, gama glutamil transferase-GGT), and biochemical parameters were analyzed using diagnostic kits. Also, kidney changes were evaluated by immunohistochemical and stereological methods. GS treatment induced significant elevation (
P
< 0.05) in kidney and hepatic markers, most of biochemical parameters, and Bax immunoreactivity as well. However, co treatments with both doses of PG (100 and 200 mg/kg/day) significantly alleviated (
P
< 0.05) the GS-induced elevations and have partially protected rats from nephrotoxicity (reduction of kidney damage, and of urea, creatinine and BUN concentrations, and of apoptotic index). Both biochemical results and immunohistochemical evidence showed that administration of PG reduced the gentamicin-induced nephrotoxicity.</description><identifier>ISSN: 1567-2379</identifier><identifier>EISSN: 1567-2387</identifier><identifier>DOI: 10.1007/s10735-012-9412-4</identifier><identifier>PMID: 22487736</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animals ; Apoptosis - drug effects ; Biomedical and Life Sciences ; Biomedicine ; Blood Urea Nitrogen ; Cell Biology ; Creatinine - blood ; Developmental Biology ; Gentamicins - toxicity ; Immunohistochemistry ; Kidney - drug effects ; Kidney - metabolism ; Kidney - pathology ; Life Sciences ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Liver Failure - chemically induced ; Liver Failure - drug therapy ; Liver Failure - pathology ; Original Paper ; Oxidative Stress - drug effects ; Panax - chemistry ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Protective Agents - chemistry ; Protective Agents - pharmacology ; Rats ; Rats, Sprague-Dawley ; Renal Insufficiency - chemically induced ; Renal Insufficiency - drug therapy ; Renal Insufficiency - pathology</subject><ispartof>Journal of molecular histology, 2012-10, Vol.43 (5), p.603-613</ispartof><rights>Springer Science+Business Media B.V. 2012</rights><rights>Springer Science+Business Media Dordrecht 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-d793682e82da1a529f87a717e7c0ba98f57222d02b7ea649c8cde31754e699e33</citedby><cites>FETCH-LOGICAL-c372t-d793682e82da1a529f87a717e7c0ba98f57222d02b7ea649c8cde31754e699e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10735-012-9412-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10735-012-9412-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22487736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalkan, Yildiray</creatorcontrib><creatorcontrib>Kapakin, Kubra Asena Terim</creatorcontrib><creatorcontrib>Kara, Adem</creatorcontrib><creatorcontrib>Atabay, Tennur</creatorcontrib><creatorcontrib>Karadeniz, Ali</creatorcontrib><creatorcontrib>Simsek, Nejdet</creatorcontrib><creatorcontrib>Karakus, Emre</creatorcontrib><creatorcontrib>Can, Ismail</creatorcontrib><creatorcontrib>Yildirim, Serap</creatorcontrib><creatorcontrib>Ozkanlar, Seckin</creatorcontrib><creatorcontrib>Sengul, Emin</creatorcontrib><title>Protective effect of Panax ginseng against serum biochemical changes and apoptosis in kidney of rats treated with gentamicin sulphate</title><title>Journal of molecular histology</title><addtitle>J Mol Hist</addtitle><addtitle>J Mol Histol</addtitle><description>The protective effects of
Panax ginseng
(PG) on gentamicin sulphate (GS) induced acute nephrotoxicity were investigated in rats. A total of 32 adult Sprague–Dawley rats were randomly divided into 4 equal groups and treated by intraperitoneous route for 10 days with: 0.5 mL of isotonic saline (group C), GS 100 mg/kg/day (group GS), co treatment PG (100 and 200 mg/kg/day) plus GS (100 mg/kg/day). After the last injection, kidney markers (urea, creatinine and blood urea nitrogen-BUN) and hepatic markers (aspartate aminotransferase-AST, alanine aminotransferase-ALT, gama glutamil transferase-GGT), and biochemical parameters were analyzed using diagnostic kits. Also, kidney changes were evaluated by immunohistochemical and stereological methods. GS treatment induced significant elevation (
P
< 0.05) in kidney and hepatic markers, most of biochemical parameters, and Bax immunoreactivity as well. However, co treatments with both doses of PG (100 and 200 mg/kg/day) significantly alleviated (
P
< 0.05) the GS-induced elevations and have partially protected rats from nephrotoxicity (reduction of kidney damage, and of urea, creatinine and BUN concentrations, and of apoptotic index). Both biochemical results and immunohistochemical evidence showed that administration of PG reduced the gentamicin-induced nephrotoxicity.</description><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Urea Nitrogen</subject><subject>Cell Biology</subject><subject>Creatinine - blood</subject><subject>Developmental Biology</subject><subject>Gentamicins - toxicity</subject><subject>Immunohistochemistry</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Life Sciences</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver Failure - chemically induced</subject><subject>Liver Failure - drug therapy</subject><subject>Liver Failure - pathology</subject><subject>Original Paper</subject><subject>Oxidative Stress - drug effects</subject><subject>Panax - chemistry</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Protective Agents - chemistry</subject><subject>Protective Agents - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Renal Insufficiency - chemically induced</subject><subject>Renal Insufficiency - drug therapy</subject><subject>Renal Insufficiency - pathology</subject><issn>1567-2379</issn><issn>1567-2387</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kM1OwzAQhC0EglJ4AC7IEueA7fzYOaKKPwmJHuAcbZ1N6tI6wXaAPgDvjatCxYWLPdLOzGo_Qs44u-SMySvPmUzzhHGRlFl8sj0y4nkhE5Equb_Tsjwix94vGBOqyMpDciREpqRMixH5mrouoA7mHSk2TVS0a-gULHzS1liPtqXQQlSBenTDis5Mp-e4MhqWVM_Btugp2JpC3_Wh88ZTY-mrqS2uN1UOgqfBIQSs6YcJc9qiDRDz0eaHZT-PkxNy0MDS4-nPPyYvtzfPk_vk8enuYXL9mOhUipDUskwLJVCJGjjkomyUBMklSs1mUKoml0KImomZRIiXaqVrTLnMMyzKEtN0TC62vb3r3gb0oVp0g7NxZcWZYpFJVmTRxbcu7TrvHTZV78wK3Dqaqg34agu-iuCrDfhqkzn_aR5mK6x3iV_S0SC2Bh9HEZr7u_q_1m9bYY_5</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Kalkan, Yildiray</creator><creator>Kapakin, Kubra Asena Terim</creator><creator>Kara, Adem</creator><creator>Atabay, Tennur</creator><creator>Karadeniz, Ali</creator><creator>Simsek, Nejdet</creator><creator>Karakus, Emre</creator><creator>Can, Ismail</creator><creator>Yildirim, Serap</creator><creator>Ozkanlar, Seckin</creator><creator>Sengul, Emin</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20121001</creationdate><title>Protective effect of Panax ginseng against serum biochemical changes and apoptosis in kidney of rats treated with gentamicin sulphate</title><author>Kalkan, Yildiray ; Kapakin, Kubra Asena Terim ; Kara, Adem ; Atabay, Tennur ; Karadeniz, Ali ; Simsek, Nejdet ; Karakus, Emre ; Can, Ismail ; Yildirim, Serap ; Ozkanlar, Seckin ; Sengul, Emin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-d793682e82da1a529f87a717e7c0ba98f57222d02b7ea649c8cde31754e699e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Apoptosis - 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Panax ginseng
(PG) on gentamicin sulphate (GS) induced acute nephrotoxicity were investigated in rats. A total of 32 adult Sprague–Dawley rats were randomly divided into 4 equal groups and treated by intraperitoneous route for 10 days with: 0.5 mL of isotonic saline (group C), GS 100 mg/kg/day (group GS), co treatment PG (100 and 200 mg/kg/day) plus GS (100 mg/kg/day). After the last injection, kidney markers (urea, creatinine and blood urea nitrogen-BUN) and hepatic markers (aspartate aminotransferase-AST, alanine aminotransferase-ALT, gama glutamil transferase-GGT), and biochemical parameters were analyzed using diagnostic kits. Also, kidney changes were evaluated by immunohistochemical and stereological methods. GS treatment induced significant elevation (
P
< 0.05) in kidney and hepatic markers, most of biochemical parameters, and Bax immunoreactivity as well. However, co treatments with both doses of PG (100 and 200 mg/kg/day) significantly alleviated (
P
< 0.05) the GS-induced elevations and have partially protected rats from nephrotoxicity (reduction of kidney damage, and of urea, creatinine and BUN concentrations, and of apoptotic index). Both biochemical results and immunohistochemical evidence showed that administration of PG reduced the gentamicin-induced nephrotoxicity.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>22487736</pmid><doi>10.1007/s10735-012-9412-4</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Blood Urea Nitrogen Cell Biology Creatinine - blood Developmental Biology Gentamicins - toxicity Immunohistochemistry Kidney - drug effects Kidney - metabolism Kidney - pathology Life Sciences Liver - drug effects Liver - metabolism Liver - pathology Liver Failure - chemically induced Liver Failure - drug therapy Liver Failure - pathology Original Paper Oxidative Stress - drug effects Panax - chemistry Plant Extracts - chemistry Plant Extracts - pharmacology Protective Agents - chemistry Protective Agents - pharmacology Rats Rats, Sprague-Dawley Renal Insufficiency - chemically induced Renal Insufficiency - drug therapy Renal Insufficiency - pathology |
| title | Protective effect of Panax ginseng against serum biochemical changes and apoptosis in kidney of rats treated with gentamicin sulphate |
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