Protective effect of Panax ginseng against serum biochemical changes and apoptosis in kidney of rats treated with gentamicin sulphate

The protective effects of Panax ginseng (PG) on gentamicin sulphate (GS) induced acute nephrotoxicity were investigated in rats. A total of 32 adult Sprague–Dawley rats were randomly divided into 4 equal groups and treated by intraperitoneous route for 10 days with: 0.5 mL of isotonic saline (group...

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Veröffentlicht in:	Journal of molecular histology 2012-10, Vol.43 (5), p.603-613
Hauptverfasser:	Kalkan, Yildiray, Kapakin, Kubra Asena Terim, Kara, Adem, Atabay, Tennur, Karadeniz, Ali, Simsek, Nejdet, Karakus, Emre, Can, Ismail, Yildirim, Serap, Ozkanlar, Seckin, Sengul, Emin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Blood Urea Nitrogen Cell Biology Creatinine - blood Developmental Biology Gentamicins - toxicity Immunohistochemistry Kidney - drug effects Kidney - metabolism Kidney - pathology Life Sciences Liver - drug effects Liver - metabolism Liver - pathology Liver Failure - chemically induced Liver Failure - drug therapy Liver Failure - pathology Original Paper Oxidative Stress - drug effects Panax - chemistry Plant Extracts - chemistry Plant Extracts - pharmacology Protective Agents - chemistry Protective Agents - pharmacology Rats Rats, Sprague-Dawley Renal Insufficiency - chemically induced Renal Insufficiency - drug therapy Renal Insufficiency - pathology
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Zusammenfassung:	The protective effects of Panax ginseng (PG) on gentamicin sulphate (GS) induced acute nephrotoxicity were investigated in rats. A total of 32 adult Sprague–Dawley rats were randomly divided into 4 equal groups and treated by intraperitoneous route for 10 days with: 0.5 mL of isotonic saline (group C), GS 100 mg/kg/day (group GS), co treatment PG (100 and 200 mg/kg/day) plus GS (100 mg/kg/day). After the last injection, kidney markers (urea, creatinine and blood urea nitrogen-BUN) and hepatic markers (aspartate aminotransferase-AST, alanine aminotransferase-ALT, gama glutamil transferase-GGT), and biochemical parameters were analyzed using diagnostic kits. Also, kidney changes were evaluated by immunohistochemical and stereological methods. GS treatment induced significant elevation ( P
ISSN:	1567-2379 1567-2387
DOI:	10.1007/s10735-012-9412-4