Semiautomatic Region-of-Interest Validation at the Femur in ^sup 18^F-Fluoride PET/CT

Studies of the differential response between cortical and trabecular bone to aging, disease, and treatment may provide a better understanding of mechanisms of action of novel treatments currently being developed for osteoporosis (1,2) and allow insight into the role of regional bone turnover as a risk factor for fracture. The definition of ROIs on the PET images themselves is difficult because of low spatial resolution, high noise, low tracer uptake, and anatomic landmarks or boundaries that are difficult to visualize. [...]the manual ROI definition by experts is a time-consuming process and is susceptible to high variability.