Stratified mucin producing intraepithelial lesion

ABSTRACT We report a case of stratified mucin producing intraepithelial lesion (SMILE), associated with adenocarcinoma and human papillomavirus (HPV) 18 infection. A 54‐year‐old lady presented with vaginal bleeding for 2 months. A punchy biopsy in private clinic showed papillary neoplasm composed of stratified columnar epithelium showing intracytoplasmic mucin vacuole. Microscopic examination for following cone biopsy demonstrated adenocarcinoma along with SMILE, and HPV 18 was detected by DNA chip examination. After several immunohistochemical stainings, SMILE showed predominant glandular differentiation.