A072: A comparison of 24 hour blood pressure in hypertensive patients switched from amlodipine to nisoldipine

A072: A comparison of 24 hour blood pressure in hypertensive patients switched from amlodipine to nisoldipine

Blood pressure control and medication costs are two important parts in antihypertensive drug product selection. Within a therapeutic drug class, acquisition costs many times take precedence over efficacy. The purpose of this study was to evaluate 24 hour blood pressure control and adverse effects in...

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Veröffentlicht in:American journal of hypertension 2000-04, Vol.13 (S2), p.138A-138A
Hauptverfasser: Hilleman, D.E., Mohiuddin, S.M., Wurdeman, R.L., Lenz, T.L.
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ambulatory blood pressure
Amlodipine
nisoldipine
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container_end_page 138A
container_issue S2
container_start_page 138A
container_title American journal of hypertension
container_volume 13
creator Hilleman, D.E.
Mohiuddin, S.M.
Wurdeman, R.L.
Lenz, T.L.
description Blood pressure control and medication costs are two important parts in antihypertensive drug product selection. Within a therapeutic drug class, acquisition costs many times take precedence over efficacy. The purpose of this study was to evaluate 24 hour blood pressure control and adverse effects in patients with essential hypertension when switched from Amlodipine (A) to Nisoldipine (N). Hypertensive patients stabilized on A 5 mg or 10 mg were monitored over 24 hours with an ambulatory blood pressure monitor (AMBP). The following day the patients were switched to (N) 10 mg (≥65 yrs old) or 20 mg (
doi_str_mv 10.1016/S0895-7061(00)00605-1
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Results thus far have shown no significant difference between (A) and (N) with regards to mean 24 hr AMBP (+1.8 mm Hg/+2.4 mm Hg), daytime (+1.3/+2.5) and nighttime (+2.6/+2) blood pressures and diurnal variation (10.1%/11.3% vs. 9.1%/11.6%, Sys/Dia (A) vs. (N)). Three dose titrations have occurred and no significant adverse events were reported. AWP for low dose (A) is $1.29/day vs. $0.93 of (N). High dose AWP is $2.50 vs. $0.93 for (A) and (N), respectively. 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Results thus far have shown no significant difference between (A) and (N) with regards to mean 24 hr AMBP (+1.8 mm Hg/+2.4 mm Hg), daytime (+1.3/+2.5) and nighttime (+2.6/+2) blood pressures and diurnal variation (10.1%/11.3% vs. 9.1%/11.6%, Sys/Dia (A) vs. (N)). Three dose titrations have occurred and no significant adverse events were reported. AWP for low dose (A) is $1.29/day vs. $0.93 of (N). High dose AWP is $2.50 vs. $0.93 for (A) and (N), respectively. 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Results thus far have shown no significant difference between (A) and (N) with regards to mean 24 hr AMBP (+1.8 mm Hg/+2.4 mm Hg), daytime (+1.3/+2.5) and nighttime (+2.6/+2) blood pressures and diurnal variation (10.1%/11.3% vs. 9.1%/11.6%, Sys/Dia (A) vs. (N)). Three dose titrations have occurred and no significant adverse events were reported. AWP for low dose (A) is $1.29/day vs. $0.93 of (N). High dose AWP is $2.50 vs. $0.93 for (A) and (N), respectively. Based on the data obtained thus far, patients taking (A) can be safely and effectively switched to (N).</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1016/S0895-7061(00)00605-1</doi></addata></record>
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source Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
subjects ambulatory blood pressure
Amlodipine
nisoldipine
title A072: A comparison of 24 hour blood pressure in hypertensive patients switched from amlodipine to nisoldipine
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