Hyperosmolar, increased-anion-gap metabolic acidosis and hyperglycemia after etomidate infusion

Abstract Hyperosmolar increased-anion-gap metabolic acidosis without hyperglycemia has been reported after infusions of etomidate and other medications containing propylene glycol. We report a case of this biochemical abnormality with severe hyperglycemia. Cessation of the etomidate infusion along w...

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Veröffentlicht in:	Journal of clinical anesthesia 2008-06, Vol.20 (4), p.290-293
Hauptverfasser:	Ganesh, Arjunan, MBBS, Audu, Paul, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-Base Equilibrium - drug effects Acidosis - chemically induced Adult Anesthesia Anesthesia & Perioperative Care Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Intravenous - adverse effects Biological and medical sciences Blood Chemical Analysis Diabetes Etomidate Etomidate - adverse effects Female Glucose Humans Hyperglycemia Hyperglycemia - chemically induced Hyperosmolar metabolic acidosis Medical sciences Pain Medicine Pharmaceutical industry Propylene glycol Propylene Glycol - metabolism Propylene Glycol - poisoning Solvents - metabolism Solvents - poisoning Treatment Outcome
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Zusammenfassung:	Abstract Hyperosmolar increased-anion-gap metabolic acidosis without hyperglycemia has been reported after infusions of etomidate and other medications containing propylene glycol. We report a case of this biochemical abnormality with severe hyperglycemia. Cessation of the etomidate infusion along with other supportive measures resulted in prompt resolution of the metabolic acidosis and hyperglycemia.
ISSN:	0952-8180 1873-4529
DOI:	10.1016/j.jclinane.2007.12.010