Induction and activation of macrophage transforming growth factor- [beta] 1 by extracellular nicotinamide adenine dinucleotide (NAD+) and its metabolite, cyclic ADP ribose: In vitro and in silico studies

Induction and activation of macrophage transforming growth factor- [beta] 1 by extracellular nicotinamide adenine dinucleotide (NAD+) and its metabolite, cyclic ADP ribose: In vitro and in silico studies

Conclusions NAD+, thus, joins proteases, plasmin, chaotropic agents, acid pH, radiation, and oxygen and nitrogen free radicals as a novel agent capable of activating TGF-β1. Because NAD+ may be liberated from injured tissues, NAD+ may be a novel anti-inflammatory damage-associated molecular pattern...

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Veröffentlicht in:Journal of critical care 2012-06, Vol.27 (3), p.e10
Hauptverfasser: Zamora, Ruben, Metukuri, Mallikarjuna, Namas, Rajaie, Azhar, Nabil, Namas, Rami, Constantine, Gregory, Billiar, Timothy, Fink, Mitchell, Vodovotz, Yoram
Format: Artikel
Sprache:eng
Schlagworte:
Enzymes
Free radicals
Ordinary differential equations
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Zusammenfassung:Conclusions NAD+, thus, joins proteases, plasmin, chaotropic agents, acid pH, radiation, and oxygen and nitrogen free radicals as a novel agent capable of activating TGF-β1. Because NAD+ may be liberated from injured tissues, NAD+ may be a novel anti-inflammatory damage-associated molecular pattern molecule.
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2012.01.030