Nebulized imipenem to control nosocomial pneumonia caused by Pseudomonas aeruginosa
Though his muscle power improved and the forced vital capacity increased to 25 mL kg-1, he could not be weaned off mechanical ventilation because of impaired gas exchange and signs of respiratory muscle fatigue during weaning trials. A volume-controlled mode is preferred with the following settings...
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| Veröffentlicht in: | Journal of critical care 2008-03, Vol.23 (1), p.148-150 |
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| creator | Radhakrishnan, M., MD, DM Jaganath, A., DNB Rao, G.S. Umamaheswara, MD Kumari, H.B.Veena, MD |
| description | Though his muscle power improved and the forced vital capacity increased to 25 mL kg-1, he could not be weaned off mechanical ventilation because of impaired gas exchange and signs of respiratory muscle fatigue during weaning trials. A volume-controlled mode is preferred with the following settings to facilitate lung sedimentation of aerosol particles in the alveolar space: constant and low inspiratory flow, a minute ventilation limited to 6 L min-1, a respiratory frequency of 12 breaths min-1, an inspiratory-to-expiratory ratio of 50%, and an end-inspiratory pause that constitutes 20% of the duty cycle. |
| doi_str_mv | 10.1016/j.jcrc.2007.10.037 |
| format | Article |
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| ispartof | Journal of critical care, 2008-03, Vol.23 (1), p.148-150 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Adult Aerosols Anti-Bacterial Agents - administration & dosage Antibiotics Critical Care Drug dosages Humans Imipenem - administration & dosage Infections Lungs Male Nebulizers and Vaporizers Pneumonia Pneumonia, Ventilator-Associated - diagnostic imaging Pneumonia, Ventilator-Associated - drug therapy Pneumonia, Ventilator-Associated - microbiology Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - diagnostic imaging Pseudomonas Infections - drug therapy Radiography Ventilation Ventilators |
| title | Nebulized imipenem to control nosocomial pneumonia caused by Pseudomonas aeruginosa |
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