Nebulized imipenem to control nosocomial pneumonia caused by Pseudomonas aeruginosa

Though his muscle power improved and the forced vital capacity increased to 25 mL kg-1, he could not be weaned off mechanical ventilation because of impaired gas exchange and signs of respiratory muscle fatigue during weaning trials. A volume-controlled mode is preferred with the following settings to facilitate lung sedimentation of aerosol particles in the alveolar space: constant and low inspiratory flow, a minute ventilation limited to 6 L min-1, a respiratory frequency of 12 breaths min-1, an inspiratory-to-expiratory ratio of 50%, and an end-inspiratory pause that constitutes 20% of the duty cycle.