Transcriptional Response to GAA Deficiency in Mice and Humans

Transcriptional Response to GAA Deficiency in Mice and Humans

[...]though inflammatory infiltrate is not consistently observed in the muscles of either GAA knockout mice or Pompe patients, we observed substantial inductions of immune-related genes in both species.

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Veröffentlicht in:Clinical therapeutics 2011-06, Vol.33 (6), p.S25-S25
Hauptverfasser: Palermo, A, Palmer, R, So, K, Zhang, M, Richards, B, Shah, S, Finn, P, Oba-Shinjo, S, Pescatori, M, Marie, S, McVie-Wylie, A, Mattaliano, R, Pomponio, R, Madden, S, Klinger, K
Format: Artikel
Sprache:eng
Schlagworte:
Gene expression
Internal Medicine
Medical Education
Medical research
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Zusammenfassung:[...]though inflammatory infiltrate is not consistently observed in the muscles of either GAA knockout mice or Pompe patients, we observed substantial inductions of immune-related genes in both species.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2011.05.066