Cardiac conduction disturbances after an overdose of nefazodone and gabapentin

Based on this patient's ingestion history, clinical presentation, and laboratory data, we believe that overdoses of nefazodone and gabapentin were primarily responsible for the pathophysiologic course described. [...]despite the potential complexity of this patient's pharmacologic picture,...

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Veröffentlicht in:The American journal of emergency medicine 2006-11, Vol.24 (7), p.886-888
Hauptverfasser: Rasimas, Joseph J., Burkhart, Keith K.
Format: Artikel
Sprache:eng
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Zusammenfassung:Based on this patient's ingestion history, clinical presentation, and laboratory data, we believe that overdoses of nefazodone and gabapentin were primarily responsible for the pathophysiologic course described. [...]despite the potential complexity of this patient's pharmacologic picture, we present this case so that other physicians would also monitor patients for electrocardiographic changes after nefazodone and/or gabapentin ingestion. [...]one retrospective study on antidepressant overdoses indicated that nefazodone has a more favorable safety profile than the selective serotonin reuptake inhibitors with no comparatively significant difference in QRS or QTc interval [15].
ISSN:0735-6757
1532-8171
DOI:10.1016/j.ajem.2006.03.011