Improving Proton Relaxivity of Dendritic MRI Contrast Agents by Rigid Silsesquioxane Core

We report that the cubic octameric polyhedral oligomeric silsesquioxanes (POSS)-core dendrimers, novel gadolinium (Gd) chelators, enhanced the proton relaxivity to Gd 3+ . The stability of the Gd complex with POSS(G1.5) was similar to those of DOTA and DTPA. From the MTT assay with the primary hepat...

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Veröffentlicht in:	Polymer journal 2009-01, Vol.41 (4), p.287-292
Hauptverfasser:	Tanaka, Kazuo, Kitamura, Narufumi, Naka, Kensuke, Morita, Masahito, Inubushi, Toshiro, Chujo, Moeko, Nagao, Masaya, Chujo, Yoshiki
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Biological and medical sciences Biomaterials Bioorganic Chemistry Chemistry Chemistry and Materials Science Chemistry/Food Science Exact sciences and technology Inorganic and organomineral polymers Investigative techniques, diagnostic techniques (general aspects) Medical sciences Miscellaneous. Technology Physicochemistry of polymers Polymer Sciences Preparation Radiodiagnosis. Nmr imagery. Nmr spectrometry regular-article Surfaces and Interfaces Thin Films
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Zusammenfassung:	We report that the cubic octameric polyhedral oligomeric silsesquioxanes (POSS)-core dendrimers, novel gadolinium (Gd) chelators, enhanced the proton relaxivity to Gd 3+ . The stability of the Gd complex with POSS(G1.5) was similar to those of DOTA and DTPA. From the MTT assay with the primary hepatocytes, the cytotoxicity of [Gd 2 POSS(G1.5)]2 − showed lower than that of the [Gd(DOTA)] − complex. The detection limits were approximately 100-fold improved than those of DOTA and DTPA-Gd complexes in the MR images.
ISSN:	0032-3896 1349-0540
DOI:	10.1295/polymj.PJ2008274