P-313: Effects of moderate smoking on arterial elasticity- in healthy European population- the seven European sites study of arterial elasticity

The purpose of the present study was to estimate non-invasively, arterial elasticity parameters using the HDI/PulseWave™ CR-2000 Cardiovascular Profiling System in healthy subjects according to smoking profile. We evaluated AE in healthy population, thus the subjects included wereeither non-smokers or smokers of less than 20 cigarettes per day. AE was evaluated in healthy European adults between the ages of 15 and 80 years with a BMI of less than 30 kg/m2. The subjects, recruited at work sites were required to complete an Assessment Profile Questionnaire that queried health history and medications. All subjects signed an Informed Consent Form. Small artery elasticity (SAE) was significantly higher in non-smokers than in mild smokers (7.36+/−2.59 vs 6.52+/−2.43, p=0.048). Large artery elasticity (LAE) was of borderline significance (15.93+/−4.19 vs 14.92+/−2.98, p=0.05). Analysis for smoking dose revealed the following parameters significantly correlated to smoking dose: SAE (r= −0.113, p=0.0048), estimated SV (r= −0.149, p=0.009), estimated CO (r= −0.143, p=0.012). We conclude that AE in modest smokers of a few cigarettes per day is lower than in non-smokers.