P-422: Inhibitory effects of fluvastatin on the proliferation of vascular smooth muscle cells from spontaneously hypertensive rats

P-422: Inhibitory effects of fluvastatin on the proliferation of vascular smooth muscle cells from spontaneously hypertensive rats

This study was to investigate the effects of fluvastatin on the proliferation of vascular smooth muscle cells derived from spontaneously hypertensive rats (SHR). The aorta smooth muscle cells (ASMC) derived from SHR were cultured. Proliferation of cultured ASMC were determined by direct cell number...

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Veröffentlicht in:American journal of hypertension 2001-04, Vol.14 (S1), p.172A-172A
Hauptverfasser: Liangdi, Xie, Zhihong, Lin, Kegui, Wu, Ming, Sun, Hongyan, Zhou
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Sprache:eng
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Fluvastatin
Mevalonate acid
Vascular smooth muscle cell
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container_issue S1
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container_title American journal of hypertension
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creator Liangdi, Xie
Zhihong, Lin
Kegui, Wu
Ming, Sun
Hongyan, Zhou
description This study was to investigate the effects of fluvastatin on the proliferation of vascular smooth muscle cells derived from spontaneously hypertensive rats (SHR). The aorta smooth muscle cells (ASMC) derived from SHR were cultured. Proliferation of cultured ASMC were determined by direct cell number counting and 3H-TdR incorporation. Data expressed as mean±SD of 5 determinations performed in triplicate. It was showed that the increased cell number and 3H-TdR incorporation induced by 10-6M AngII and 10ng •mL-1PDGF was significantly inhibited by fluvastatin in a concentration-dependent manner from 10-7 to 10-5M. 10-5M fluvastatin produced a 73% and 64% inhibition of cell number increase, 75% and 81% inhibition of 3H-TdR incorporation induced by 10-6M AngII and 10ng •mL-1PDGF (P
doi_str_mv 10.1016/S0895-7061(01)01580-1
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ispartof American journal of hypertension, 2001-04, Vol.14 (S1), p.172A-172A
issn 0895-7061
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1879-1905
language eng
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source Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
subjects Fluvastatin
Mevalonate acid
Vascular smooth muscle cell
title P-422: Inhibitory effects of fluvastatin on the proliferation of vascular smooth muscle cells from spontaneously hypertensive rats
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