P-422: Inhibitory effects of fluvastatin on the proliferation of vascular smooth muscle cells from spontaneously hypertensive rats

This study was to investigate the effects of fluvastatin on the proliferation of vascular smooth muscle cells derived from spontaneously hypertensive rats (SHR). The aorta smooth muscle cells (ASMC) derived from SHR were cultured. Proliferation of cultured ASMC were determined by direct cell number counting and 3H-TdR incorporation. Data expressed as mean±SD of 5 determinations performed in triplicate. It was showed that the increased cell number and 3H-TdR incorporation induced by 10-6M AngII and 10ng •mL-1PDGF was significantly inhibited by fluvastatin in a concentration-dependent manner from 10-7 to 10-5M. 10-5M fluvastatin produced a 73% and 64% inhibition of cell number increase, 75% and 81% inhibition of 3H-TdR incorporation induced by 10-6M AngII and 10ng •mL-1PDGF (P