P-477: Biochemical and cardiovascular determinants of altered flow-mediated brachial artery dilatation
Introduction: Arterial endothelial dysfunction precedes structural atherosclerotic changes, predisposing to constriction and/or thrombosis in the late stages. Aims: 1.To determine the prevalence of abnormal flow-mediated dilatation (FMD) 2. To determine its correlation with constitutional, biochemic...
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| Veröffentlicht in: | American journal of hypertension 2005-05, Vol.18 (S4), p.180A-180A |
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| creator | Haurie, Jorge Fabregate, Martin Bernal, Enrique Monge, Begonia Trueba, Angela Mendieta, Covadonga Fabregate, Rosa Calbacho, Maria Saban-Ruiz, Jose |
| description | Introduction: Arterial endothelial dysfunction precedes structural atherosclerotic changes, predisposing to constriction and/or thrombosis in the late stages. Aims: 1.To determine the prevalence of abnormal flow-mediated dilatation (FMD) 2. To determine its correlation with constitutional, biochemical and hemodynamic characteristics. 3.To correlate FMD with endothelial function markers (PAI-1). Methods: N=76, aged 60,53+-1,72; M/F ratio: 36/40; 56 Hypertensive. Gly, creat, uric acid, HDL, LDL, chol, tg by Hitachi. Glomerular filtration rate(GFR): ml/min:Cockcroft-Gault equation.PAI-1(ng/mL): Menarini EIA. Ambulatory blood pressure monitoring (ABPM): activity (9:00 to 22:00), rest (22:00 to 6:00) an critical (6:00 to 9:00) periods: average systolic BP (SBP), diastolic (DBP), and mean blood pressure (MBP). Endothelial Systolic and Diastolic Blood Pressure Burden (SBP>110, DBP>65 mmHg pressure reading percentages (ESBPB and EDBPB). Endothelium-dependent and -independent vasodilation (EDV and EIV): Celermajer method. Microcirculatory: laser Doppler MOOR DRT4. Large artery elasticity index(C1), Small artery elasticity index(C2):HDI/PulseWave CR-2000. Statistical: t-student, chi-square, multivariate analysis. Results: 1. The prevalence of abnormal brachial artery FMD ( |
| doi_str_mv | 10.1016/j.amjhyper.2005.03.494 |
| format | Article |
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Aims: 1.To determine the prevalence of abnormal flow-mediated dilatation (FMD) 2. To determine its correlation with constitutional, biochemical and hemodynamic characteristics. 3.To correlate FMD with endothelial function markers (PAI-1). Methods: N=76, aged 60,53+-1,72; M/F ratio: 36/40; 56 Hypertensive. Gly, creat, uric acid, HDL, LDL, chol, tg by Hitachi. Glomerular filtration rate(GFR): ml/min:Cockcroft-Gault equation.PAI-1(ng/mL): Menarini EIA. Ambulatory blood pressure monitoring (ABPM): activity (9:00 to 22:00), rest (22:00 to 6:00) an critical (6:00 to 9:00) periods: average systolic BP (SBP), diastolic (DBP), and mean blood pressure (MBP). Endothelial Systolic and Diastolic Blood Pressure Burden (SBP>110, DBP>65 mmHg pressure reading percentages (ESBPB and EDBPB). Endothelium-dependent and -independent vasodilation (EDV and EIV): Celermajer method. Microcirculatory: laser Doppler MOOR DRT4. Large artery elasticity index(C1), Small artery elasticity index(C2):HDI/PulseWave CR-2000. Statistical: t-student, chi-square, multivariate analysis. Results: 1. The prevalence of abnormal brachial artery FMD (<5 %) was N=54 (70,1%). 2. A statistically significant correlation was found with BMI (p=0,030), GFR (p=0,042), and uric acid (p=0,042), but not with age nor sex gender.3. We found a significant correlation between C1 and hyperemia (p=0,046), and C1 and SNTD(%) : p=0,022), but not with FMD. 4. We found no correlation between C2 and FMD, hyperemia nor SNTD 5. In FMD<5 group we found lower relative variation of post-peak recovering concentration (p=0,034) and in two of the ABPM parameters: ESBPB (p=0,015); and SBP in critical period (p=0,040). 6. A significant correlation was found between FMD and PAI-1 levels (p=0,04): Conclusions: 1-We have found a prevalence of ED=70%. 2-Large artery elasticity index correlated with EDV and EIV. 3-In ED patients there are microcirculatory alterations in the recovery phase after ischemia. 4-GFR and uricemia correlated with endothelial function 5-We have found a correlation between FMD and SBP but not with DBP. 6-PAI-1 is a reliable marker of the endothelial function in the macrocirculation.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>EISSN: 1879-1905</identifier><identifier>DOI: 10.1016/j.amjhyper.2005.03.494</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Brachial Artery ; Celermajer Method ; Pai-1</subject><ispartof>American journal of hypertension, 2005-05, Vol.18 (S4), p.180A-180A</ispartof><rights>Copyright Nature Publishing Group May 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Haurie, Jorge</creatorcontrib><creatorcontrib>Fabregate, Martin</creatorcontrib><creatorcontrib>Bernal, Enrique</creatorcontrib><creatorcontrib>Monge, Begonia</creatorcontrib><creatorcontrib>Trueba, Angela</creatorcontrib><creatorcontrib>Mendieta, Covadonga</creatorcontrib><creatorcontrib>Fabregate, Rosa</creatorcontrib><creatorcontrib>Calbacho, Maria</creatorcontrib><creatorcontrib>Saban-Ruiz, Jose</creatorcontrib><title>P-477: Biochemical and cardiovascular determinants of altered flow-mediated brachial artery dilatation</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>Introduction: Arterial endothelial dysfunction precedes structural atherosclerotic changes, predisposing to constriction and/or thrombosis in the late stages. Aims: 1.To determine the prevalence of abnormal flow-mediated dilatation (FMD) 2. To determine its correlation with constitutional, biochemical and hemodynamic characteristics. 3.To correlate FMD with endothelial function markers (PAI-1). Methods: N=76, aged 60,53+-1,72; M/F ratio: 36/40; 56 Hypertensive. Gly, creat, uric acid, HDL, LDL, chol, tg by Hitachi. Glomerular filtration rate(GFR): ml/min:Cockcroft-Gault equation.PAI-1(ng/mL): Menarini EIA. Ambulatory blood pressure monitoring (ABPM): activity (9:00 to 22:00), rest (22:00 to 6:00) an critical (6:00 to 9:00) periods: average systolic BP (SBP), diastolic (DBP), and mean blood pressure (MBP). Endothelial Systolic and Diastolic Blood Pressure Burden (SBP>110, DBP>65 mmHg pressure reading percentages (ESBPB and EDBPB). Endothelium-dependent and -independent vasodilation (EDV and EIV): Celermajer method. Microcirculatory: laser Doppler MOOR DRT4. Large artery elasticity index(C1), Small artery elasticity index(C2):HDI/PulseWave CR-2000. Statistical: t-student, chi-square, multivariate analysis. Results: 1. The prevalence of abnormal brachial artery FMD (<5 %) was N=54 (70,1%). 2. A statistically significant correlation was found with BMI (p=0,030), GFR (p=0,042), and uric acid (p=0,042), but not with age nor sex gender.3. We found a significant correlation between C1 and hyperemia (p=0,046), and C1 and SNTD(%) : p=0,022), but not with FMD. 4. We found no correlation between C2 and FMD, hyperemia nor SNTD 5. In FMD<5 group we found lower relative variation of post-peak recovering concentration (p=0,034) and in two of the ABPM parameters: ESBPB (p=0,015); and SBP in critical period (p=0,040). 6. A significant correlation was found between FMD and PAI-1 levels (p=0,04): Conclusions: 1-We have found a prevalence of ED=70%. 2-Large artery elasticity index correlated with EDV and EIV. 3-In ED patients there are microcirculatory alterations in the recovery phase after ischemia. 4-GFR and uricemia correlated with endothelial function 5-We have found a correlation between FMD and SBP but not with DBP. 6-PAI-1 is a reliable marker of the endothelial function in the macrocirculation.</description><subject>Brachial Artery</subject><subject>Celermajer Method</subject><subject>Pai-1</subject><issn>0895-7061</issn><issn>1941-7225</issn><issn>1879-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpF0MtKw0AUBuBBFKzVV5AB14kzmVviTou1irdFF-ImnMyFTMylThK1b29KBVeHn_PxHzgInVMSU0LlZRVDU5XbjQ1xQoiICYt5xg_QjGacRipJxCGakTQTkSKSHqOTvq8IIVxKOkPuNeJKXeEb3-nSNl5DjaE1WEMwvvuCXo81BGzsYEPjW2iHHncOQz1la7Cru--oscbDMKUigC79riFM6y02voYBBt-1p-jIQd3bs785R-vl7Xqxih5f7u4X14-Rz2gSacksS5TTwgCXnKTOuNRqJgjnymhmpbGuYNyYAgrHbCGtKrI0ceCEyIRic3Sxr92E7nO0_ZBX3Rja6WJOSSIVUZInk8J71cIwBptvgm8gbHOoyt0DVSYmEu2J7wf78y_CRy4VUyJfvb3n7EE9yycq8iX7BaCydrs</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Haurie, Jorge</creator><creator>Fabregate, Martin</creator><creator>Bernal, Enrique</creator><creator>Monge, Begonia</creator><creator>Trueba, Angela</creator><creator>Mendieta, Covadonga</creator><creator>Fabregate, Rosa</creator><creator>Calbacho, Maria</creator><creator>Saban-Ruiz, Jose</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20050501</creationdate><title>P-477: Biochemical and cardiovascular determinants of altered flow-mediated brachial artery dilatation</title><author>Haurie, Jorge ; Fabregate, Martin ; Bernal, Enrique ; Monge, Begonia ; Trueba, Angela ; Mendieta, Covadonga ; Fabregate, Rosa ; Calbacho, Maria ; Saban-Ruiz, Jose</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i912-c63e327fc5da46408fdf8ec350447dc3e6defb34ddbabf3eb6e7b982faf559573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Brachial Artery</topic><topic>Celermajer Method</topic><topic>Pai-1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haurie, Jorge</creatorcontrib><creatorcontrib>Fabregate, Martin</creatorcontrib><creatorcontrib>Bernal, Enrique</creatorcontrib><creatorcontrib>Monge, Begonia</creatorcontrib><creatorcontrib>Trueba, Angela</creatorcontrib><creatorcontrib>Mendieta, Covadonga</creatorcontrib><creatorcontrib>Fabregate, Rosa</creatorcontrib><creatorcontrib>Calbacho, Maria</creatorcontrib><creatorcontrib>Saban-Ruiz, Jose</creatorcontrib><collection>Istex</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haurie, Jorge</au><au>Fabregate, Martin</au><au>Bernal, Enrique</au><au>Monge, Begonia</au><au>Trueba, Angela</au><au>Mendieta, Covadonga</au><au>Fabregate, Rosa</au><au>Calbacho, Maria</au><au>Saban-Ruiz, Jose</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P-477: Biochemical and cardiovascular determinants of altered flow-mediated brachial artery dilatation</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>18</volume><issue>S4</issue><spage>180A</spage><epage>180A</epage><pages>180A-180A</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><eissn>1879-1905</eissn><coden>AJHYE6</coden><abstract>Introduction: Arterial endothelial dysfunction precedes structural atherosclerotic changes, predisposing to constriction and/or thrombosis in the late stages. Aims: 1.To determine the prevalence of abnormal flow-mediated dilatation (FMD) 2. To determine its correlation with constitutional, biochemical and hemodynamic characteristics. 3.To correlate FMD with endothelial function markers (PAI-1). Methods: N=76, aged 60,53+-1,72; M/F ratio: 36/40; 56 Hypertensive. Gly, creat, uric acid, HDL, LDL, chol, tg by Hitachi. Glomerular filtration rate(GFR): ml/min:Cockcroft-Gault equation.PAI-1(ng/mL): Menarini EIA. Ambulatory blood pressure monitoring (ABPM): activity (9:00 to 22:00), rest (22:00 to 6:00) an critical (6:00 to 9:00) periods: average systolic BP (SBP), diastolic (DBP), and mean blood pressure (MBP). Endothelial Systolic and Diastolic Blood Pressure Burden (SBP>110, DBP>65 mmHg pressure reading percentages (ESBPB and EDBPB). Endothelium-dependent and -independent vasodilation (EDV and EIV): Celermajer method. Microcirculatory: laser Doppler MOOR DRT4. Large artery elasticity index(C1), Small artery elasticity index(C2):HDI/PulseWave CR-2000. Statistical: t-student, chi-square, multivariate analysis. Results: 1. The prevalence of abnormal brachial artery FMD (<5 %) was N=54 (70,1%). 2. A statistically significant correlation was found with BMI (p=0,030), GFR (p=0,042), and uric acid (p=0,042), but not with age nor sex gender.3. We found a significant correlation between C1 and hyperemia (p=0,046), and C1 and SNTD(%) : p=0,022), but not with FMD. 4. We found no correlation between C2 and FMD, hyperemia nor SNTD 5. In FMD<5 group we found lower relative variation of post-peak recovering concentration (p=0,034) and in two of the ABPM parameters: ESBPB (p=0,015); and SBP in critical period (p=0,040). 6. A significant correlation was found between FMD and PAI-1 levels (p=0,04): Conclusions: 1-We have found a prevalence of ED=70%. 2-Large artery elasticity index correlated with EDV and EIV. 3-In ED patients there are microcirculatory alterations in the recovery phase after ischemia. 4-GFR and uricemia correlated with endothelial function 5-We have found a correlation between FMD and SBP but not with DBP. 6-PAI-1 is a reliable marker of the endothelial function in the macrocirculation.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1016/j.amjhyper.2005.03.494</doi></addata></record> |
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| subjects | Brachial Artery Celermajer Method Pai-1 |
| title | P-477: Biochemical and cardiovascular determinants of altered flow-mediated brachial artery dilatation |
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