P-477: Biochemical and cardiovascular determinants of altered flow-mediated brachial artery dilatation

Introduction: Arterial endothelial dysfunction precedes structural atherosclerotic changes, predisposing to constriction and/or thrombosis in the late stages. Aims: 1.To determine the prevalence of abnormal flow-mediated dilatation (FMD) 2. To determine its correlation with constitutional, biochemical and hemodynamic characteristics. 3.To correlate FMD with endothelial function markers (PAI-1). Methods: N=76, aged 60,53+-1,72; M/F ratio: 36/40; 56 Hypertensive. Gly, creat, uric acid, HDL, LDL, chol, tg by Hitachi. Glomerular filtration rate(GFR): ml/min:Cockcroft-Gault equation.PAI-1(ng/mL): Menarini EIA. Ambulatory blood pressure monitoring (ABPM): activity (9:00 to 22:00), rest (22:00 to 6:00) an critical (6:00 to 9:00) periods: average systolic BP (SBP), diastolic (DBP), and mean blood pressure (MBP). Endothelial Systolic and Diastolic Blood Pressure Burden (SBP>110, DBP>65 mmHg pressure reading percentages (ESBPB and EDBPB). Endothelium-dependent and -independent vasodilation (EDV and EIV): Celermajer method. Microcirculatory: laser Doppler MOOR DRT4. Large artery elasticity index(C1), Small artery elasticity index(C2):HDI/PulseWave CR-2000. Statistical: t-student, chi-square, multivariate analysis. Results: 1. The prevalence of abnormal brachial artery FMD (