Evaluation in mice of some iodinated melanoma imaging agents using cryosectioning and multi-wire proportional counting
AMBIS 4000, a multi-wire proportional counter, was calibrated for iodine-125 measurements. The detector displayed a linear response over a wide dynamic range. Using whole-body mice cryosections, a linear relationship could be established between count rate per area (cpm/mm2) measured with the AMBIS...
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| Veröffentlicht in: | European journal of nuclear medicine 1999-05, Vol.26 (5), p.494-498 |
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| container_title | European journal of nuclear medicine |
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| creator | LABARRE, P PAPON, J MOREAU, M.-F MOINS, N VEYRE, A MADELMONT, J.-C |
| description | AMBIS 4000, a multi-wire proportional counter, was calibrated for iodine-125 measurements. The detector displayed a linear response over a wide dynamic range. Using whole-body mice cryosections, a linear relationship could be established between count rate per area (cpm/mm2) measured with the AMBIS 4000 detector and the count rate per gram (dpm/g) determined with an NaI(Tl) scintillation detector. A calibration curve could, thus be constructed. This new method allowed direct visual and quantitative evaluation of the biodistribution of a short series of 125I-labelled benzamides in melanoma-bearing mice. All the compounds studied showed good tumoral targeting ability. For one of them, ortho-N-(2-diethylaminoethyl)-4-iodobenzamide, liver and lung uptake decreased rapidly after dosing, making it a suitable tracer for scintigraphic detection of malignant melanoma. |
| doi_str_mv | 10.1007/s002590050416 |
| format | Article |
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The detector displayed a linear response over a wide dynamic range. Using whole-body mice cryosections, a linear relationship could be established between count rate per area (cpm/mm2) measured with the AMBIS 4000 detector and the count rate per gram (dpm/g) determined with an NaI(Tl) scintillation detector. A calibration curve could, thus be constructed. This new method allowed direct visual and quantitative evaluation of the biodistribution of a short series of 125I-labelled benzamides in melanoma-bearing mice. All the compounds studied showed good tumoral targeting ability. For one of them, ortho-N-(2-diethylaminoethyl)-4-iodobenzamide, liver and lung uptake decreased rapidly after dosing, making it a suitable tracer for scintigraphic detection of malignant melanoma.</description><identifier>ISSN: 0340-6997</identifier><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s002590050416</identifier><identifier>PMID: 10382093</identifier><identifier>CODEN: EJNMD9</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Benzamides ; Biological and medical sciences ; Cryoultramicrotomy - methods ; Investigative techniques, diagnostic techniques (general aspects) ; Iodine Radioisotopes ; Male ; Medical sciences ; Melanoma, Experimental - diagnostic imaging ; Mice ; Mice, Inbred C57BL ; Miscellaneous. Technology ; Radionuclide Imaging ; Radionuclide investigations ; Radiopharmaceuticals - pharmacokinetics ; Scintillation Counting - instrumentation ; Skin Neoplasms - diagnostic imaging ; Tissue Distribution</subject><ispartof>European journal of nuclear medicine, 1999-05, Vol.26 (5), p.494-498</ispartof><rights>1999 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-45dec8bf327252250740f7537e6b7334aede89ed435862573002a5b28eb040bb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1789706$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10382093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LABARRE, P</creatorcontrib><creatorcontrib>PAPON, J</creatorcontrib><creatorcontrib>MOREAU, M.-F</creatorcontrib><creatorcontrib>MOINS, N</creatorcontrib><creatorcontrib>VEYRE, A</creatorcontrib><creatorcontrib>MADELMONT, J.-C</creatorcontrib><title>Evaluation in mice of some iodinated melanoma imaging agents using cryosectioning and multi-wire proportional counting</title><title>European journal of nuclear medicine</title><addtitle>Eur J Nucl Med</addtitle><description>AMBIS 4000, a multi-wire proportional counter, was calibrated for iodine-125 measurements. The detector displayed a linear response over a wide dynamic range. Using whole-body mice cryosections, a linear relationship could be established between count rate per area (cpm/mm2) measured with the AMBIS 4000 detector and the count rate per gram (dpm/g) determined with an NaI(Tl) scintillation detector. A calibration curve could, thus be constructed. This new method allowed direct visual and quantitative evaluation of the biodistribution of a short series of 125I-labelled benzamides in melanoma-bearing mice. All the compounds studied showed good tumoral targeting ability. For one of them, ortho-N-(2-diethylaminoethyl)-4-iodobenzamide, liver and lung uptake decreased rapidly after dosing, making it a suitable tracer for scintigraphic detection of malignant melanoma.</description><subject>Animals</subject><subject>Benzamides</subject><subject>Biological and medical sciences</subject><subject>Cryoultramicrotomy - methods</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Iodine Radioisotopes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma, Experimental - diagnostic imaging</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Miscellaneous. Technology</subject><subject>Radionuclide Imaging</subject><subject>Radionuclide investigations</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Scintillation Counting - instrumentation</subject><subject>Skin Neoplasms - diagnostic imaging</subject><subject>Tissue Distribution</subject><issn>0340-6997</issn><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0Utr3DAQAGARGpLNtsdei6AhN6ejl2UdS0jSwkIvydnI8nhRsKWNZKfk30fbXUjbkxDzzTAPQj4zuGYA-lsG4MoAKJCsPiErVjNTaWjMB7ICIaGqjdHn5CLnJwCQUqgzcs5ANByMWJGX2xc7Lnb2MVAf6OQd0jjQHCekPvY-2Bl7OuFoQ5ws9ZPd-rCldothznTJ-49LrzGj29f4EwslYRlnX_32CekuxV1M-6AdqYtLmAv6SE4HO2b8dHzX5PHu9uHmR7X5df_z5vumcpLxuZKqR9d0g-CaK84VaAmDVkJj3WkhpMUeG4N9maqpudKiLMOqjjfYgYSuE2tydahbunheMM_t5LPDsYyDccltbRqplWEFfv0PPsUllZZzy4DXxWlhiqoOyqWYc8Kh3aWykvRaULs_R_vPOYr_cqy6dBP2f-nD_gu4PAKbnR2HZIPz-d3pxmioxRuqnJJr</recordid><startdate>19990501</startdate><enddate>19990501</enddate><creator>LABARRE, P</creator><creator>PAPON, J</creator><creator>MOREAU, M.-F</creator><creator>MOINS, N</creator><creator>VEYRE, A</creator><creator>MADELMONT, J.-C</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19990501</creationdate><title>Evaluation in mice of some iodinated melanoma imaging agents using cryosectioning and multi-wire proportional counting</title><author>LABARRE, P ; PAPON, J ; MOREAU, M.-F ; MOINS, N ; VEYRE, A ; MADELMONT, J.-C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-45dec8bf327252250740f7537e6b7334aede89ed435862573002a5b28eb040bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Benzamides</topic><topic>Biological and medical sciences</topic><topic>Cryoultramicrotomy - methods</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Iodine Radioisotopes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanoma, Experimental - diagnostic imaging</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Miscellaneous. 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The detector displayed a linear response over a wide dynamic range. Using whole-body mice cryosections, a linear relationship could be established between count rate per area (cpm/mm2) measured with the AMBIS 4000 detector and the count rate per gram (dpm/g) determined with an NaI(Tl) scintillation detector. A calibration curve could, thus be constructed. This new method allowed direct visual and quantitative evaluation of the biodistribution of a short series of 125I-labelled benzamides in melanoma-bearing mice. All the compounds studied showed good tumoral targeting ability. For one of them, ortho-N-(2-diethylaminoethyl)-4-iodobenzamide, liver and lung uptake decreased rapidly after dosing, making it a suitable tracer for scintigraphic detection of malignant melanoma.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>10382093</pmid><doi>10.1007/s002590050416</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0340-6997 |
| ispartof | European journal of nuclear medicine, 1999-05, Vol.26 (5), p.494-498 |
| issn | 0340-6997 1619-7070 1619-7089 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Benzamides Biological and medical sciences Cryoultramicrotomy - methods Investigative techniques, diagnostic techniques (general aspects) Iodine Radioisotopes Male Medical sciences Melanoma, Experimental - diagnostic imaging Mice Mice, Inbred C57BL Miscellaneous. Technology Radionuclide Imaging Radionuclide investigations Radiopharmaceuticals - pharmacokinetics Scintillation Counting - instrumentation Skin Neoplasms - diagnostic imaging Tissue Distribution |
| title | Evaluation in mice of some iodinated melanoma imaging agents using cryosectioning and multi-wire proportional counting |
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